Lopinavir/Ritonavir Tablet (200 mg/50 mg) combines two protease inhibitors: lopinavir, the active antiviral agent, and ritonavir, which boosts plasma levels by inhibiting CYP3A metabolism — a cornerstone in HIV-1 treatment.

Mechanism of Action

Lopinavir inhibits HIV-1 protease, preventing viral protein cleavage and viral maturation. Ritonavir acts as a pharmacokinetic enhancer by inhibiting CYP3A4 metabolism, increasing lopinavir’s bioavailability. ([turn0search10])

Dosage & Administration

Adults: 400 mg/100 mg (two tablets) twice daily, or 800 mg/200 mg once daily in selected cases. Tablets may be taken with or without food; do not crush or chew. Pediatric dosing is weight-based. ([turn0search1])

Common Side Effects

Most frequent: diarrhoea, nausea, vomiting, headache, fatigue, elevated triglycerides and cholesterol. Severe effects may include pancreatitis, elevated blood sugar, liver dysfunction. ([turn0search2], [turn0search3], [turn0search10])

Warnings & Precautions

• Strong CYP3A4 inhibitor — high risk of drug interactions; review concomitant medications carefully. ([turn0search11], [turn0search8])
• Monitor for hepatotoxicity, hyperglycaemia, lipodystrophy, and cardiac conduction changes.
• Use with caution during pregnancy; consult clinical guidelines.

Disclaimer

This product information is for educational and catalog use only. It does not replace clinical advice. Always follow a healthcare provider’s prescription.

Abamune-L Tablet contains Abacavir 600 mg and Lamivudine 300 mg, two NRTIs used together in HIV-1 combination therapy to inhibit reverse transcriptase and reduce viral replication.

Mechanism of Action

Both Abacavir and Lamivudine act as nucleoside reverse transcriptase inhibitors, blocking the enzyme required for viral DNA synthesis and inhibiting HIV replication. ([turn0search0], [turn0search2])

Dosage & Administration

Take one tablet once daily at the same time each day, with or without food. Do not split or crush the tablet. ([turn0search11])

Side Effects & Precautions

• Common: headache, fatigue, nausea, rash, fever.
• Serious: hypersensitivity reactions—HLA-B*5701 screening is recommended before initiating Abacavir. Use caution in pregnancy and avoid alcohol. Monitor hepatic function regularly.

Disclaimer

For product listing purposes only. This information is not a substitute for medical advice. Always follow healthcare provider instructions.