Overview

Lopinavir/Ritonavir Tablet (200 mg/50 mg) combines two protease inhibitors: lopinavir, the active antiviral agent, and ritonavir, which boosts plasma levels by inhibiting CYP3A metabolism — a cornerstone in HIV-1 treatment.

Mechanism of Action

Lopinavir inhibits HIV-1 protease, preventing viral protein cleavage and viral maturation. Ritonavir acts as a pharmacokinetic enhancer by inhibiting CYP3A4 metabolism, increasing lopinavir’s bioavailability. ([turn0search10])

Dosage & Administration

Adults: 400 mg/100 mg (two tablets) twice daily, or 800 mg/200 mg once daily in selected cases. Tablets may be taken with or without food; do not crush or chew. Pediatric dosing is weight-based. ([turn0search1])

Common Side Effects

Most frequent: diarrhoea, nausea, vomiting, headache, fatigue, elevated triglycerides and cholesterol. Severe effects may include pancreatitis, elevated blood sugar, liver dysfunction. ([turn0search2], [turn0search3], [turn0search10])

Warnings & Precautions

• Strong CYP3A4 inhibitor — high risk of drug interactions; review concomitant medications carefully. ([turn0search11], [turn0search8])
• Monitor for hepatotoxicity, hyperglycaemia, lipodystrophy, and cardiac conduction changes.
• Use with caution during pregnancy; consult clinical guidelines.

Disclaimer

This product information is for educational and catalog use only. It does not replace clinical advice. Always follow a healthcare provider’s prescription.